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REVIEW ARTICLE
Year : 2021  |  Volume : 1  |  Issue : 2  |  Page : 71-77

Review of the application of dMMR and microsatellite instability in the diagnosis and treatment of endometrial cancer


1 Department of Pathology, Red Cross Hospital of Yulin, Yulin, Guangxi, China
2 Department of Pathology; Department of Obstetrics and Gynecology, Red Cross Hospital of Yulin, Yulin, Guangxi, China
3 Department of Pathology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China

Correspondence Address:
Prof. Guangjie Liao
Department of Pathology, Red Cross Hospital of Yulin, No. 1, Jin Wang Road, Yuzhou, Yulin City, Guangxi
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/aort.aort_20_21

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Mismatch repair genes are responsible for discovering and repairing base mismatches during DNA replication in cells. Defects in mismatch repair function will lead to accumulation of gene mutations, microsatellite instability, and ultimately tumorigenesis. Mismatch repair genes are closely related to the biological behavior, patient prognosis, and related treatments of endometrial cancer. This article reviews the research progress of mismatch repair defect (dMMR) in the diagnosis and treatment of endometrial cancer.


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