• Users Online: 59
  • Print this page
  • Email this page
CASE REPORT
Year : 2022  |  Volume : 2  |  Issue : 2  |  Page : 101-103

“Wnt/β-catenin-activated Ewing's sarcoma with metastasis to pancreas:” A rare case report


Department of Oncopathology, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India

Correspondence Address:
Dr. Shilpa Kapoor
Department of Oncopathology, Room 412, First Floor, New Cancer Building, Gujarat Cancer and Research Institute, Ahmedabad - 380 016, Gujarat
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/aort.aort_17_22

Rights and Permissions

Ewing's sarcoma (ES) family of tumors are aggressive tumors with high metastatic potential. Various unusual sites of metastasis have been reported, with pancreas being one of the exceptional sites. Herein, we report a case of a 21-year-old biopsied for a pancreatic mass and its histopathological evaluation revealed infiltration by a malignant small round cell tumor. Given that the patient was under treatment for ES of the right iliac bone an immunohistochemistry panel applied showed CD99, FLI-1 positivity proving it to be a metastasis. Furthermore, β-catenin put on clinical suspicion of solid pseudopapillary neoplasm was positive. Recent evidence suggest that elevated β-catenin expression is associated with poor outcomes, signifying Wnt/β-catenin signaling pathway contributes to disease progression. We not only report an uncommon metastasis of ES to the pancreas with four other cases reported so far but we also attempt to analyze probable correlation of β-catenin to disease advancement and its prognostic implication.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed28    
    Printed2    
    Emailed0    
    PDF Downloaded2    
    Comments [Add]    

Recommend this journal